Nifedipine nanoparticle agglomeration as a dry powder aerosol formulation strategy
نویسندگان
چکیده
منابع مشابه
Dry powder inhaler formulation.
A drug product combines pharmacologic activity with pharmaceutical properties. Desirable performance characteristics are physical and chemical stability, ease of processing, accurate and reproducible delivery to the target organ, and availability at the site of action. For the dry powder inhaler (DPI), these goals can be met with a suitable powder formulation, an efficient metering system, and ...
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The Aim of this study was preparation of dry powder formulation of rifampicin loaded polymeric microparticles as dry powder formulation for inhalation in effective tuberculosis treatment.The microparticles containing rifampicin (RIF) were prepared by spray drying method using different biocompatible polymers like chitosan and hydroxyl propyl methyl cellulose (HPMC) The microparticles and microp...
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Nanoparticle technology represents an attractive approach for formulating poorly water-soluble pulmonary medicines. Unfortunately, nanoparticle suspensions used in nebulizers or metered dose inhalers often suffer from physical instability in the form of uncontrolled agglomeration or Ostwald ripening. In addition, processing such suspensions into dry powders can yield broad particle size distrib...
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BACKGROUND Nanosized dry powder inhalers provide higher stability for poorly water-soluble drugs as compared with liquid formulations. However, the respirable particles must have a diameter of 1-5 μm in order to deposit in the lungs. Controlled agglomeration of the nanoparticles increases their geometric particle size so they can deposit easily in the lungs. In the lungs, they fall apart to ref...
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Inhaled drug delivery is an important part of the armamentarium of clinicians caring for patients with pulmonary disease. An increasing variety of metered-dose inhalers and dry powder inhalers are becoming available. This has been driven by the development of new formulations and the impending ban on chlorofluorocarbon propellants. The result is a proliferation of devices, resulting in a confus...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2009
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2008.10.016